Sports Talk Baseball, released in Japan as Pro Yakyuu Super League '91 (プロ野球スーパーリーグ'９１), is a Mega Drive/Genesis baseball video game which features an official MLBPA license as well as most rules and aspects followed by Major League Baseball.

Unlike real professional baseball however, the game ends when one team has 10 or more runs than the other team (win by domination, or "mercy" rule). Players can play either exhibition, regular season, all-star, or playoff games. It was one of the first video games to feature individual hitting abilities for each pitcher.

The most valuable (hitting) player in the game is Howard Johnson of the New York Mets. HoJo has the full capability in both running and hitting. He also has the ability to play infield and outfield.

It is considered to be one of the best baseball video games. Rant Sports rated it the eleventh best baseball video game in history. Stack rated the game as one of the top 10 video baseball games of all time. Bleacher Report rated Sports Talk Baseball as the twelfth best baseball video game of all time and referred to it as a "gem."