Teenage Mutant Ninja Turtles is a 2003 Game Boy Advance video game, based on the 2003 TV series. In this game each turtle has his own unique set of levels to complete. In addition to the traditional side-scrolling levels, there are third-person view races, a shell-glider level for Donatello and a bike race between Raphael and Casey Jones. The game was also issued in a double pack with its sequel TMNT 2: Battle Nexus.

Teenage Mutant Ninja Turtles is a regular beat 'em up platform game. After the player chooses one of the Ninja Turtles, each of whom has a special ability, the character enters a set of four acts, one of which is a vehicle-riding minigame. Leonardo can crawl through small spaces and rides the hovercraft Sewer Slider for a rail shooter minigame. Michelangelo can wall jump, and rides a skateboard through the sewers. Donatello climbs pipes and has a shoot 'em up level using a hang glider. Raphael uses his sai to climb walls and has a motorcycle racing minigame riding the Shell Cycle against Casey Jones.