Jack Nicklaus' Greatest 18 Holes of Major Championship Golf is a golf-simulation video game developed by Sculptured Software, and published by Accolade beginning in 1988. It was released for Amiga, Amstrad CPC, Apple IIGS, Atari ST, Commodore 64 (C64), MS-DOS, Macintosh, MSX, Nintendo Entertainment System (NES), PC-88, and Sharp X68000.

During 1990 and 1991, the game was released in HuCard cartridge and CD-ROM formats for the U.S TurboGrafx-16 and its foreign counterpart, PC Engine. The TurboGrafx-16 versions of the game were titled Jack Nicklaus' Turbo Golf, while the PC Engine version was titled Jack Nicklaus World Golf Tour for the CD-ROM format. A Game Boy version was released as Jack Nicklaus Golf in 1992.

It was the first in a series of golf games named after golfer Jack Nicklaus, and was followed by Jack Nicklaus' Unlimited Golf & Course Design (1990).

The game features Jack Nicklaus' favorite 18 golf holes, all put together in a single course, which includes holes from Augusta National Golf Club, Muirfield, Pebble Beach Golf Links, Royal Lytham & St Annes Golf Club, and Old Course at St Andrews. Two courses designed by Nicklaus are also featured in the game: Castle Pines (Colorado) and Desert Mountain (Arizona). Additionally, the Game Boy version includes Muirfield Village as a course. Several add-on disks were released for the computer versions to add additional courses.

The game features two game modes: Stroke Play and Skins. A multiplayer option allows for a maximum total of four players being able to play. The player can also compete against a selection of eight different CPU players that includes Jack Nicklaus. An image of Nicklaus also appears in between holes as he gives tips to the player.

Jack Nicklaus' Turbo Golf, for the TurboGrafx-16, differs from the other versions. In CD-ROM format, the game has five courses, including Castle Pines. The other courses were previously featured in the game's early add-on disks: The Australian Golf Club, Royal Troon Golf Club, Kemper Lakes Golf Club, and St. Creek Golf Club. The CD-ROM version allows the player to take a 360-degree look around any of the courses, and Nicklaus appears in between courses to give advice about each hole. The HuCard cartridge version of Jack Nicklaus' Turbo Golf includes only one course, The Australian Golf Club, and includes eight golfer rivals, as well as Jack Nicklaus.