The Simpsons: Night of the Living Treehouse of Horror is a platform game published by THQ on March 19, 2001, for the Game Boy Color. Developed by Software Creations, it is based on the Treehouse of Horror episodes of the animated television series The Simpsons. The game features seven side-scrolling levels in which the player controls the members of the Simpson family. Night of the Living Treehouse of Horror has received average reviews from critics, with praise directed at the design.

The Simpsons: Night of the Living Treehouse of Horror is a side-scrolling platformer. The game features seven levels, each one of which re-creates a tale from the annual Treehouse of Horror episodes of the American animated television series The Simpsons. All five members of the Simpson family have their own level, with the exception of Homer, who has three. The levels include Marge in a zombie tale, Maggie as a fly, Lisa fighting cannibalistic teachers, Bart rescuing Santa's Little Helper in a haunted house, and Homer as a vampire killer, a robot, and the large ape King Homer.