Star Trek: 25th Anniversary is a 1992 adventure video game developed by Interplay and published by Ultra Games for the Nintendo Entertainment System. A different version was made with the same name (not a port) on the Game Boy.

Kirk leads an away team consisting of the player's choice of two crew members including but not limited to McCoy, Spock, and even red shirts down to a planet, each one constitutes a level. The gameplay becomes graphic adventure game-styled. Most of the time, progress in the game requires the player to interact with various life forms on a world, find objects, and solve puzzles. While each character is equipped with a phaser, violence rarely is the ideal solution to any puzzle.

In one level where the player steps on symbols on the ground to advance, the symbols from the back of Led Zeppelin IV are seen.