Spy vs. Spy is a video game written by Michael Riedel for the Commodore 64 and published by First Star Software in 1984. A port for the Atari 8-bit family was released simultaneously. It is a two-player, split-screen game, based on Mad magazine's long-running cartoon strip Spy vs. Spy, about the slapstick antics of two spies trying to kill each other with improbably elaborate traps and weapons.

It was ported to the Apple II, ZX Spectrum, Acorn Electron, Atari ST, BBC Micro, Commodore 16, MSX, Amstrad CPC, Amiga, Master System, Game Boy, Game Boy Color, and Nintendo Entertainment System, which was emulated on the Game Boy Advance.