Spider-Man is a 2000 action-adventure video game based on the Marvel Comics character of the same name. It was developed by Neversoft and published by Activision using the Tony Hawk's Pro Skater game engine for the PlayStation 1. The game was later ported by different developers to various systems, including the Game Boy Color and Nintendo 64 that same year, as well as the Dreamcast and Microsoft Windows in 2001.

The game's story follows Spider-Man as he attempts to clear his name after being framed by a doppelgänger and becoming a wanted criminal, while also having to foil a symbiote invasion orchestrated by Doctor Octopus and Carnage. Numerous villains from the comics appear as bosses, including Scorpion, Rhino, Venom, Mysterio, Carnage, and Doctor Octopus, as well as a Carnage symbiote-possessed Doctor Octopus named Monster-Ock, who was created exclusively for the game as the final boss.

The game features narration from co-creator Stan Lee, and is the first Spider-Man game published by Activision following their acquisition of the license, which would expire in 2014.

Spider-Man received an overall generally positive reception. It was followed by three sequels in 2001: the Game Boy Color-exclusive Spider-Man 2: The Sinister Six, developed by Torus Games; the PlayStation-exclusive Spider-Man 2: Enter Electro, developed by Vicarious Visions; and the Game Boy Advance-exclusive Spider-Man: Mysterio's Menace, also developed by Vicarious Visions.