X-Men: Reign of Apocalypse is a video game for the Game Boy Advance featuring the X-Men comic book characters. It was designed by Digital Eclipse and released by Activision in 2001.

X-Men: Reign of Apocalypse is a side-scrolling action beat 'em up with 12 distinct levels. Each level has waves of enemies plus a mutant boss who all must be defeated to progress to the next stage. Players must defeat enemies to earn points which can be spent at the end of each stage to improve the character's strength, vitality, or mutant power. All playable characters share the same basic attacks, but each one has a unique special ability: Wolverine has claws that excel in close-range combat, Rogue has a charge ability, Storm controls tornado projectiles, and Cyclops has long-range optic blasts.