One Piece for the Game Boy Advance is an action game released exclusively for the American handheld market. It loosely adapts the entire East Blue Saga, chronicling the adventures of the first five Straw Hat Pirates and their ultimate voyage for the Grand Line. It was developed by Dimps Corporation, published by Bandai, and released in the United States in September 2005.

As it was made in tandem with the 4Kids anime, the game uses many of the same naming conventions.

The game is a conventional side-scrolling beat-'em-up, featuring Luffy as the sole playable character against a variety of enemies. Luffy begins with several of his trademark techniques, both short- and long-range; as the game progresses, several more can be unlocked to supplement both combat and exploration.

In addition to a standard life bar (tied to a finite number of lives), Luffy carries a multi-tier "power" bar to fuel his stronger attacks with. This bar is recharged whenever Luffy successfully hits an enemy; different attacks supply different amounts of charge.