Ultima VI: The False Prophet is the sixth game in the series, and the last part of the "Age of Enlightenment" trilogy. It was published and released in 1990 by Origin for the IBM PC. Ports for the Atari ST and Commodore 64 followed in 1991. A port for the Amiga was released in 1992. Ports for the FM-Towns in 1992 and the Super NES in 1993 were next.

There are big changes in the graphics and gameplay of Ultima VI when compared to previous games. Gone are the notorious tiled graphics, different scales, and 3D dungeons from all previous Ultimas; Everything is now shown from a isometric perspective, with attention to detail in a seamless world, making Britannia look much more realistic. Though the graphics are tile-based, the tiles are integrated in a way that doesn't make them so independent from each other, but only as parts of the bigger world. Castles, towns and dungeons are in the same scale as the overworld, unlike previous Ultimas, where entering any of these places would move the player to a separate, differently-scaled map.

Every character now has a portrait when spoken to, the inventory is now graphical, the game is mouse-driven, and the characters and story have become more complex and mature than they were in Ultima V. Music support is available for the first time in the PC version.